![]() ![]() It is also used to treat acute dystonia including torticollis and oculogyric crisis caused by first generation antipsychotics.īecause of its sedative properties, diphenhydramine is widely used in nonprescription sleep aids for insomnia. Movement disorders ĭiphenhydramine is used to treat akathisia and Parkinson's disease–like extrapyramidal symptoms caused by antipsychotics. These are used to relieve itching and have the advantage of causing fewer systemic effects ( e.g., drowsiness) than oral forms. Topical formulations of diphenhydramine are available, including creams, lotions, gels, and sprays. Medical uses Ī bottle of topical "Itch-Stopping Gel" diphenhydramine In 2020, it was the 192nd most commonly prescribed medication in the United States, with more than 2 million prescriptions. It is sold under the brand name Benadryl, among others. ĭiphenhydramine was first made by George Rieveschl and came into commercial use in 1946. Its sedative and deliriant effects have led to some cases of recreational use and addiction. Diphenhydramine is also a potent anticholinergic, which means it also works as a deliriant at much higher than recommended doses as a result. It is a first-generation H 1-antihistamine and ethanolamine and works by blocking certain effects of histamine, which produces its antihistamine and sedative effects. There is no clear risk of harm when used during pregnancy however, use during breastfeeding is not recommended. Its use is not recommended in young children or the elderly. Ĭommon side effects include sleepiness, poor coordination and an upset stomach. Maximal effect is typically around two hours after a dose, and effects can last for up to seven hours. It is taken by mouth, injected into a vein, injected into a muscle, or applied to the skin. It is also less commonly used for tremor in parkinsonism, and nausea. Diphenhydramine ( DPH) is an antihistamine and sedative mainly used to treat allergies, insomnia, and symptoms of the common cold. ![]()
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